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KMID : 1094720070120060625
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Biotechnology and Bioprocess Engineering
2007 Volume.12 No. 6 p.625 ~ p.633
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Separation of racemic bupivacaine using Simulated Moving Bed with mathematical model
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Choi Young-Jae
Han Soon-Koo
Chung Sung-Taik
Row Kyung-Ho
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Abstract
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Utilizing a Simulated Moving Bed (SMB), the conditions for separating bupivacaine enantiomers, a racemic local anesthetic, were determined by triangle theory and simulations using the gPROMS software and the Aspen Chromatography package. The SMB model in this study assumed an axial dispersion flow for the liquid phase and the intraparticle mass transfer was described in terms of a simple Linear Driving Force (LDF) approximation. The parameters (a andb) of the Langmuir Adsorption Isotherm (LAI) were determined using a dynamic method. In the optimal condition the calculated concentrations were confirmed by the experimental results. Values projected by the gPROMS software more closely matched experimental values than those projected by the Aspen Chromatography package.
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KEYWORD
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chiral separation, simulated moving bed, gPROMS, Aspen Chromatography, optimal condition
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